Scientists May Have Finally Found A Way To Cure HIV

“This protection would be long term,” said first author Jia Xie.

The researchers, led by senior study author Richard Lerner, plan to collaborate with investigators at City of Hope’s Center for Gene Therapy to evaluate this new therapy in efficacy and safety tests, as required by federal regulations, before testing in patients.

“City of Hope currently has active clinical trials of gene therapy for AIDS using blood stem cell transplantation, and this experience will be applied to the task of bringing this discovery to the clinic,” said researcher John A. Zaia. “The ultimate goal will be the control of HIV in patients with AIDS without the need for other medications.”

“We at TSRI are honored to be able to collaborate with physicians and scientists at City of Hope, whose expertise in transplantation in HIV patients should hopefully allow this therapy to be used in people,” added Lerner.

The new TSRI technique offers a significant advantage over therapies where antibodies float freely in the bloodstream at a relatively low concentration. Instead, antibodies in the new study hang on to a cell’s surface, blocking HIV from accessing a crucial cell receptor and spreading infection.

Xie called it the “neighbor effect.” An antibody stuck nearby is more effective than having many antibodies floating throughout the bloodstream. “You don’t need to have so many molecules in one cell to be effective,” he said.

Before testing their system against HIV, the scientists used rhinovirus (responsible for many cases of the common cold) as a model. They used a vector called lentivirus to deliver a new gene to cultured human cells. This gene instructed cells to synthesise antibodies that bind to the human cell receptor (ICAM-1) that rhinovirus needs. With the antibodies monopolising that site, the virus cannot enter the cell to spread infection.

“This is really a form of cellular vaccination,” said Lerner.

Because the delivery system can’t reach exactly 100 percent of cells, the finished product was a mix of engineered and unengineered cells. The researchers then added rhinovirus to these cell populations and waited to see what would happen.

The vast majority of cells died in about two days. In dishes with only unengineered cells, the population never recovered. There was an initial die-off in the mixed, engineered/unengineered populations, too, but their numbers quickly bounced back. After 125 hours, these cell populations were back up to around the same levels as cells in an undiseased control group.

In essence, the researchers had forced the cells to compete in Darwinian, “survival-of-the-fittest” selection in a lab dish. Cells without antibody protection died off, leaving protected cells to survive and multiply, passing on the protective gene to new cells.

This success led the researchers to test the same technique against HIV

To infect a person, all strains of HIV need to bind with a cell surface receptor called CD4. So the scientists tested antibodies that could potentially protect this receptor on the very immune cells normally killed by HIV. “This research is possible because of the ability to select specialized antibodies from combinatorial antibody libraries,” said Lerner.

hiv_ribbon

Again, their technique worked. After introducing cells to the virus, the researchers ended up with an HIV- resistant population. The antibodies recognized the CD4 binding site, blocking HIV from getting to the receptor.

The scientists further confirmed that these tethered antibodies blocked HIV more effectively than free-floating, soluble antibodies in experiments led by study co-authors Devin Sok of the International AIDS Vaccine Initiative (IAVI) and TSRI Professor Dennis R. Burton, who is also scientific director of the IAVI Neutralizing Antibody Center and of the National Institutes of Health’s Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) at TSRI.

Joseph Alvarnas, M.D., director of Value-Based Analytics at City of Hope, explained how the TSRI technique could help patients, who, despite treatment with anti-retroviral drugs, still suffer from higher rates of diseases, such as cancers.

“HIV is treatable but not curable; this remains a disease that causes a lot of suffering. That makes the case for why these technologies are so important,” he said.

In addition to potentially collaborating with City of Hope, Xie said the next step in this research is to try engineering antibodies to protect a different receptor on the cell surface.

The study is published in the journal Proceedings of the National Academy of Sciences

Source:

http://www.indiatimes.com/health/scientists-may-have-finally-found-a-way-to-cure-hiv-275511.html

 

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One thought on “Scientists May Have Finally Found A Way To Cure HIV”

  1. in my secreet search for a solution to my virus(HIV Aids) which i contacted through sex, i meet a man (HERBAL DOCTOR) in Ghana, after so many other, he was able to give me a permanent cure to the virus, and now i am totally free from the virus, before him i have met others in different country mainly in africa which was not able to give me a cure, i met some in nigeria, tanzania, kenya, south africa, i did all they asked me and i wan not cure within their stipulated time, thank God i did not lose hope, because i knew the life of my kids and that of my husband would soon be destroy if i relent in getting a cure, now i am medically and naturally fine. If you think that sickness is a good thing, then you can keep quite and die out of ignorance, if you do not want anybody to laugh you, i guess you would want them to cry you, if you hide your Tears you will die in silence, But i will advice you never to choose to die such a miserable death because i was once a victim who was suffering from a very deadly virus known as hiv aids, i suffered from this virus for about 2 years. did everything humanly possible to cure the virus, It to a point where i decided not continue with the treatment because i had spent a lot of money and all seem to be in vain, Until a faithful day while i was reading a comment on internet, I came across a testimony of a man called mark, He stated in his comment that he suffered from herpes for about 14 years and didn’t believe that he could be cured once again, He said it was a herbal doctor called DOC AHONVI located in Ghana, After reading all he wrote, i decided to contact the herbal doctor, After several communication with him, He promised that my virus will be cured, I believed him because he spoke with great confidence, So after 7 days, I received a call from the herbal doctor that my medicine was ready, So the herbal doctor asked for my location address and sent the medicine over to me, Today is the 90 days after my medication administered by the herbal doctor, I can tell you all that i am healthy now and living my normal life, all thanks to this great herbal doctor call, DOCTOR AHONVI. If you need his service of any kind, Feel free to contact him through his email or whatsapp no. Email:(hjoshua. smile at gmail.com) whatsapp : +233237776431

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